Glioblastoma: Example of Translational Research in Radiotherapy and Radiobiology: J. Attal, J. Khalifa, and E. Cohen-Jonathan Moyal

Radiotherapy , , ,

Glioblastoma: Example of Translational Research in Radiotherapy and Radiobiology

J. Attal, J. Khalifa, and
E. Cohen-Jonathan Moyal
Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncopoˆ le, Toulouse, France (J.A.); Department of Radiation Oncology, Institut Universitaire du Cancer de
Toulouse-Oncopoˆ le, Toulouse, France (J.K.) Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncopoˆ le,
Toulouse, France (E.C.-J.M); INSERM U1037,
Cancer Research Center of Toulouse, Toulouse, France (E.C.-J.M); Universite´ Toulouse III Paul Sabatier, Toulouse, France (E.C.-J.M)

Corresponding author:
E. Cohen-Jonathan Moyal, Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse-Oncopoˆ le, 1
Avenue Ire` ne Joliot-Curie Toulouse 31059, France (Moyal.Elizabeth@iuct-oncopole.fr)

Glioblastoma multiforme (GBM) is an aggressive brain tumor known to be highly radioresistant due to modulation of various signal transduction pathways involving tumor cells and their microenvironment. We describe in this paper our research experience in order to better understand and encompass this radioresistance.
We chose to focus particularly on all factors controlling angiogenesis, hypoxia, and invasion, but also on the intrinsic radioresistance of glioblastomas. Thus, we decided to study the
pathway of fibroblast growth factor 2 (FGF-2), a potent angiogenic factor highly expressed in glioblastoma and its receptors (FGFR), as well as the pathway of avb3 and avb5 integrins expressed in
both GBM cells and endothelial cells. We investigated their role in the control of the hypoxia pathway, known to be involved in tumor radioresistance. Moreover, one of the hypotheses
that could explain the phenomenon of resistance to radiotherapy is the presence of tumor stem cells known to be radioresistant and dependent on FGF-2 and hypoxia. In this way, our team is also implicated in the deciphering of GBM stem cell radioresistance. Finally, our team is involved in the field of GBM

 

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